Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other indicators from the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have discovered recurrent mutations in genes regulating tumor cell-microenvironment interactions, w... https://stever530jry7.blogdeazar.com/profile